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Page Title: EXPECTORANTS AND ANTITUSSIVES
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ASTRINGENTS
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ANTIINFECTIVES

oxide  powder.  It  is  used  as  an  emollient  with slightly astringent properties, and because of its opaqueness  it  is  ideal  for  protecting  sensitive  skin from  the  sun. EXPECTORANTS   AND   ANTITUSSIVES Expectorants,  more  accurately  known  as  bron- chomucotropic agents, are drugs used to assist in the  removal  of  secretions  or  exudate  from  the trachea, bronchi, or lungs. They act by liquifying viscid mucus or mucopurulent exudates, i.e., they are  decongestants.  Therefore,  they  are  used  in  the treatment of coughs to help expel these exudates and  secretions.  Antitussives  are  agents  that  specif- ically  inhibit  or  suppress  the  act  of  coughing.  They should not be used to suppress productive cough- ing. Expectorants and antitussives are most com- monly used in the symptomatic treatment of the common   cold   or   bronchitis.   Other   cold   and allergy relief preparations are discussed later in this chapter. Guaifenesin (Robitussin) ACTION AND USE.—  Guaifenesin is an ex- pectorant.  It  may  be  useful  in  the  symptomatic relief  of  dry,  nonproductive  coughs  and  in  the presence  of  mucous  in  the  respiratory  tract. USUAL   DOSE.—   5  to  20  ml  every  4  to  6 hours. Dextromethorphan  (DM) ACTION  AND  USE.—  This  is  a  synthetic non-narcotic derivative of codeine that acts as an antitussive.  It  is  used  to  control  nonproductive coughs  by  soothing  minor  throat  and  bronchial irritations. USUAL  DOSE.—   5 to 15 ml (10 to 30 mg) every 6 to 8 hours. It is frequently combined with Guaifenesin   (Robitussin). Benzonatate (Tessalon Perles) ACTION AND USE.— Benzonatate is an an- titussive.  It  anesthetizes  the  stretch  receptors located  in  the  respiratory  passages  and  lungs, reducing the cough reflex at its source. It is used for   the   symptomatic   relief   of   nonproductive coughs. USUAL DOSE.—  One  perle  three  times  daily as  needed,  up  to  600  mg  a  day. Terpin Hydrate Elixir with Codeine (ETH with Codeine) ACTION AND USE.—  Codeine is a narcotic antitussive. The terpin hydrate is used primarily as a vehicle for the codeine but has a mild expec- torant  effect.  This  product  contains  40  percent alcohol   which   serves   as   the   main   bron- chomucotropic   agent. USUAL  DOSE.—  5 ml every 3 to 4 hours. ANTISEPTICS,  DISINFECTANTS,  AND GERMICIDES These  drugs  are  primarily  intended  for  the prevention of infections by destroying bacteria or preventing  their  growth.  The  differences  among them are based primarily on degree of activity and how they are used; antiseptics suppress the growth of  microorganisms  and  are  used  topically;  ger- micides kill susceptible organisms; and disinfec- tants  are  agents  used  on  inanimate  objects  and are  primarily  germicidal  in  their  action.  All  of these agents are for external use only unless other- wise indicated. Phenol  (Carbolic  Acid) Historically one of the first antiseptic agents used,  phenol  is  the  standard  by  which  all  other antiseptic,  disinfectant,  and  germicidal  agents  are measured  in  their  effectiveness.  Because  of  its highly  caustic  nature,  it  must  be  handled  with care. The effect of phenol is coincident with the concentration; high concentrations are germicidal and  can  cause  tissue  destruction;  lower  concen- tration  are  antiseptic.  Phenol  is  inactivated  by alcohol. Because more effective and less damag- ing  agents  have  been  developed,  phenol  is  no longer  used  extensively.  Never  use  phenol  to disinfect  rubber,  cloth,  or  plastic. Povidone-Iodine (Betadine) ACTION AND USE.— Numerous iodine and iodine  complex  agents  are  available  for  use  in disinfection.   The   most   common   of   these   is povidone-iodine (Betadine). It is used externally to destroy bacteria, fungi, viruses, protozoa, and yeasts.  It  is  relatively  nontoxic,  nonirritating,  and nonsensitizing to the skin. When used as an an- tiseptic,  the  complex  breaks  down  on  contact  with skin or mucous membranes to release free iodine which  is  slowly  absorbed.  It  is  most  commonly used as a preoperative skin antiseptic. 7 - 6

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